Makoto Aihara Selected Research

Fibrosis (Cirrhosis)

2/2024	An Autotaxin-Induced Ocular Hypertension Mouse Model Reflecting Physiological Aqueous Biomarker.
1/2024	A MEK inhibitor arrests the cell cycle of human conjunctival fibroblasts and improves the outcome of glaucoma filtration surgery.
11/2023	Effects of Brimonidine, Omidenepag Isopropyl, and Ripasudil Ophthalmic Solutions to Protect against H2O2-Induced Oxidative Stress in Human Trabecular Meshwork Cells.
1/2022	Fibrotic Response of Human Trabecular Meshwork Cells to Transforming Growth Factor-Beta 3 and Autotaxin in Aqueous Humor.
12/2021	Effect of postoperative corticosteroids on surgical outcome and aqueous autotaxin following combined cataract and microhook ab interno trabeculotomy.
6/2021	Crosstalk between transforming growth factor β-2 and Autotaxin in trabecular meshwork and different subtypes of glaucoma.
1/2021	Effects of mammalian target of rapamycin inhibitors on fibrosis after trabeculectomy.
9/2019	Activation of the Sphingosine 1 Phosphate-Rho Pathway in Pterygium and in Ultraviolet-Irradiated Normal Conjunctiva.

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Makoto Aihara Research Topics

Disease

57	Glaucoma 03/2024 - 12/2004
31	Open-Angle Glaucoma (Glaucoma, Open Angle) 03/2024 - 06/2004
25	Ocular Hypertension (Glaucoma, Suspect) 03/2024 - 04/2003
13	Low Tension Glaucoma 11/2022 - 11/2006
11	Inflammation (Inflammations) 02/2024 - 01/2018
11	Cataract (Cataracts) 12/2023 - 01/2018
10	Uveitis 12/2023 - 07/2017
8	Fibrosis (Cirrhosis) 02/2024 - 09/2019
8	Hypoxia (Hypoxemia) 01/2023 - 02/2006
8	Ganglion Cysts (Ganglion) 01/2022 - 04/2007
6	Blister (Bulla) 01/2024 - 07/2009
5	Macular Degeneration (Age-Related Maculopathy) 01/2023 - 01/2019
5	Hyperemia 01/2023 - 01/2012
5	Atrophy 01/2023 - 01/2009
4	Cicatrix (Scar) 01/2024 - 01/2017
4	Keratoconus 01/2023 - 04/2010
4	Exfoliation Syndrome 11/2021 - 03/2015
3	Keratitis 07/2023 - 01/2016
3	Corneal Edema 01/2023 - 01/2022
3	Choroidal Neovascularization 01/2023 - 11/2019
3	Diabetic Retinopathy (Retinopathy, Diabetic) 08/2022 - 01/2021
3	Pterygium 01/2021 - 12/2008
3	Acute Retinal Necrosis Syndrome 01/2021 - 01/2020
3	Sarcoidosis (Schaumann Disease) 03/2020 - 01/2019
3	Endophthalmitis (Ophthalmia) 03/2020 - 01/2020
3	Necrosis 01/2019 - 01/2011
2	Fuchs' Endothelial Dystrophy 06/2023 - 10/2022
2	Macular Edema 01/2023 - 09/2020
2	Myopia 01/2023 - 10/2022
2	Genetic Risk Score 12/2022 - 01/2020
2	Blepharitis 01/2022 - 01/2021
2	Premature Birth (Birth, Premature) 01/2022 - 12/2020
2	Infections 01/2021 - 11/2020
2	Epiretinal Membrane (Epiretinal Membranes) 01/2021 - 10/2005
2	Rheumatoid Arthritis 03/2020 - 07/2018
2	Uveomeningoencephalitic Syndrome (Vogt Koyanagi Harada Syndrome) 03/2020 - 01/2019
2	Intraocular Lymphoma 01/2020 - 10/2017
2	Corneal Neovascularization 12/2019 - 11/2019

Drug/Important Bio-Agent (IBA)

19	Retinaldehyde (Retinal)IBA 12/2023 - 08/2006
12	Ophthalmic Solutions (Eye Drops)IBA 01/2024 - 04/2010
12	Proteins (Proteins, Gene)FDA Link 12/2023 - 01/2009
10	ProstaglandinsIBA 03/2024 - 12/2017
10	Latanoprost (Xalatan)FDA Link 09/2021 - 04/2010
9	Synthetic Prostaglandins (Prostaglandin Analogues)IBA 11/2023 - 08/2012
9	Neuroprotective AgentsIBA 03/2023 - 02/2006
7	K-115IBA 03/2024 - 10/2017
7	hydroxide ionIBA 02/2024 - 10/2014
7	Glutamic Acid (Glutamate)FDA Link 01/2021 - 05/2007
6	Brimonidine Tartrate (Alphagan)FDA LinkGeneric 03/2024 - 02/2010
6	omidenepag isopropylIBA 09/2022 - 01/2019
5	Antiglaucoma AgentsIBA 05/2023 - 08/2012
5	Fluorescein (Funduscein)FDA LinkGeneric 03/2023 - 08/2018
5	Timolol (Blocadren)FDA LinkGeneric 11/2021 - 05/2007
4	Indicators and Reagents (Reagents)IBA 03/2024 - 04/2007
4	Biomarkers (Surrogate Marker)IBA 02/2024 - 01/2020
4	Glucose (Dextrose)FDA LinkGeneric 11/2023 - 01/2009
4	SteroidsIBA 08/2022 - 07/2018
4	Benzalkonium Compounds (Benzalkonium Chloride)FDA LinkGeneric 01/2020 - 12/2008
3	lysophosphatidic acidIBA 02/2024 - 01/2018
3	SphingosineIBA 12/2023 - 01/2017
3	CytokinesIBA 12/2023 - 01/2020
3	LipidsIBA 12/2023 - 07/2019
3	brinzolamide (Azopt)FDA Link 11/2023 - 12/2017
3	Carrier Proteins (Binding Protein)IBA 02/2023 - 01/2009
3	rho-Associated KinasesIBA 01/2023 - 10/2017
3	Adrenal Cortex Hormones (Corticosteroids)IBA 12/2021 - 01/2020
3	prostaglandin F2alpha receptorIBA 09/2021 - 01/2018
3	Mitomycin (Mitomycin-C)FDA LinkGeneric 08/2021 - 03/2015
3	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 12/2019 - 01/2017
3	Travoprost (Travatan)FDA Link 01/2016 - 09/2011
3	N-Methylaspartate (NMDA)IBA 05/2009 - 04/2007
2	Adrenergic Receptors (Adrenergic Receptor)IBA 03/2024 - 05/2007
2	EndotoxinsIBA 12/2023 - 10/2017
2	Phosphotransferases (Kinase)IBA 12/2023 - 11/2019
2	Sphingosine-1-Phosphate ReceptorsIBA 12/2023 - 09/2019
2	Endoplasmic Reticulum Chaperone BiPIBA 11/2023 - 01/2009
2	Messenger RNA (mRNA)IBA 11/2023 - 01/2023
2	Calcium Channel Blockers (Blockers, Calcium Channel)IBA 03/2023 - 02/2006
2	Melanins (Melanin)IBA 10/2022 - 11/2020
2	Retinal Pigments (Pigments, Visual)IBA 08/2022 - 01/2019
2	Carteolol (Carteolol Hydrochloride)FDA LinkGeneric 09/2021 - 05/2007
2	Protein Kinases (Protein Kinase)IBA 01/2021 - 01/2019
2	Long Noncoding RNAIBA 01/2021 - 11/2020
2	Methotrexate (Mexate)FDA LinkGeneric 01/2020 - 10/2017
2	LysophospholipidsIBA 12/2019 - 01/2017

Therapy/Procedure

17	Trabeculectomy (Trabeculoplasty) 12/2023 - 07/2009
16	Lasers (Laser) 03/2024 - 10/2003
8	Therapeutics 03/2024 - 12/2017
4	Filtering Surgery 01/2024 - 01/2017
4	Phacoemulsification 01/2023 - 07/2020
3	Contact Lenses 01/2023 - 06/2008
3	Vitrectomy 01/2022 - 03/2018
3	Light Coagulation 01/2012 - 10/2003
2	Eyeglasses (Spectacles) 07/2023 - 01/2021
2	Drug Therapy (Chemotherapy) 02/2023 - 10/2017
2	Laser Therapy (Surgery, Laser) 01/2023 - 11/2022
2	Anesthesia 01/2023 - 01/2020
2	Transplantation 10/2022 - 12/2019
2	Scleral Buckling 01/2022 - 01/2021
2	Slit Lamp 12/2019 - 06/2008